New Story, New Anti-hero Resistance: Retribution follows the story of former British Marine, James Grayson. A veteran of the struggle against the Chimera in Britain following their conquest of the European continent, he did not escape those battles unwounded. Months prior to his entrance into the game, while leading an attack on a Chimera conversion facility--locations where humans are changed into monstrous slaves serving the Chimera--he was forced to kill his own brother in order to keep him from turning into one of these abominations. Following this Grayson goes on a vendetta to destroy every conversion center he can find, eventually even deserting his unit to fulfill his lust for revenge, a crime which he would be locked up for. Unfortunately, for all his compulsion, success and sacrifice Grayson learns that his efforts have been futile. In Western Europe the Chimera have evolved a new method of converting humans, one about which nearly nothing is known. Aware of his experience with the Chimera, the European resistance--the Maquis--enlist Grayson's help, and he joins Cartwright and Parker in Operation Overstrike, and so the war to retake the European continent and the game begins.